Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma

Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma

SET domain-containing 2 (SETD2) is responsible for the trimethylation of histone H3 lysine36 (H3K36me3) and is one of the genes most frequently mutated in clear cell renal cell carcinoma (ccRCC). It is located at 3p21, one copy of which is lost in the majority of ccRCC tumors, suggesting that SETD2...

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Bibliographic Details
Main Authors: Jun Li, Joost Kluiver, Jan Osinga, Helga Westers, Maaike B van Werkhoven, Marc A. Seelen, Rolf H. Sijmons, Anke van den Berg, Klaas Kok
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616300185

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http://www.sciencedirect.com/science/article/pii/S1476558616300185

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