The Crimson Conundrum: Heme Toxicity and Tolerance in GAS

The Crimson Conundrum: Heme Toxicity and Tolerance in GAS

The massive erythrocyte lysis caused by the Group A Streptococcus (GAS) suggests that the β-hemolytic pathogen is likely to encounter free heme during the course of infection. In this study, we investigated GAS mechanisms for heme sensing and tolerance. We compared the minimal inhibitory concentrati...

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Bibliographic Details
Main Authors: ANKITA JAGDISH SACHLA, Yoann Stephane Le Breton, Fahmina eAkhter, Kevin S McIver, Zehava eEichenbaum
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
chaperones
Oxidative damage
transcriptome analysis
Gram-positive
Redox sensing
heme adaptation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00159/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2014.00159/full

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