Alteration of protein function by a silent polymorphism linked to tRNA abundance.

Alteration of protein function by a silent polymorphism linked to tRNA abundance.

Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids. We identified an sSNP that modifies the local translation speed of the cystic fibrosis transmembrane conductance regulator (CFTR), leading to d...

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Bibliographic Details
Main Authors: Sebastian Kirchner, Zhiwei Cai, Robert Rauscher, Nicolai Kastelic, Melanie Anding, Andreas Czech, Bertrand Kleizen, Lynda S Ostedgaard, Ineke Braakman, David N Sheppard, Zoya Ignatova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2000779

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https://doi.org/10.1371/journal.pbio.2000779

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