DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription

DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription

In eukaryotes, ribosome biogenesis is driven by the synthesis of the ribosomal RNA (rRNA) by RNA polymerase I (Pol-I) and is tightly linked to cell growth and proliferation. The 3D-structure of the rDNA promoter plays an important, yet not fully understood role in regulating rRNA synthesis. We hypot...

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Bibliographic Details
Main Authors: William J. Andrews, Swagat Ray, Tatiana Panova, Christoph Engel, Konstantin I. Panov
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Genes
Subjects:
DNA intercalators
ribosome biogenesis
ribosomal RNA
RNA polymerase I
ribosomal DNA
transcription
Online Access:https://www.mdpi.com/2073-4425/12/9/1412

Internet

https://www.mdpi.com/2073-4425/12/9/1412

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