Effects of Astragaloside IV Against the TGF-β1-Induced Epithelial-to-Mesenchymal Transition in Peritoneal Mesothelial Cells by Promoting Smad 7 Expression

Effects of Astragaloside IV Against the TGF-β1-Induced Epithelial-to-Mesenchymal Transition in Peritoneal Mesothelial Cells by Promoting Smad 7 Expression

Background/Aims: To investigate the effect of Astragaloside IV (AS-IV) on the regulation of the TGF-β1/Smad signaling pathway in peritoneal mesothelial cells with an epithelial-to-mesenchymal transition (EMT). Methods: EMT of human peritoneal mesothelial cells (HMrSV5) was induced using 2 ng/ml TGF-...

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Bibliographic Details
Main Authors: Lu Zhang, Zhenghong Li, Weiming He, Lingdong Xu, Jing Wang, Jun Shi, Meixiao Sheng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Astragaloside IV
TGF-β1
Smad7
EMT
Mesothelial cells
Peritoneal dialysis (PD)
Peritoneal fibrosis (PF)
Online Access:http://www.karger.com/Article/FullText/430332

Internet

http://www.karger.com/Article/FullText/430332

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