Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System

Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System

The pentose phosphate pathway (PPP), which branches from glycolysis, is correlated with cancer cell proliferation, survival and senescence. In this study, differences in the metabolic profile of the PPP and the redox status of human lung carcinoma A549 cells and cisplatin-induced multidrug-resistant...

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Bibliographic Details
Main Authors: Weipeng Hong, Peiheng Cai, Chuncao Xu, Di Cao, Weibang Yu, Zhongxiang Zhao, Min Huang, Jing Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
pentose phosphate pathway
G6PD
cisplatin resistance
A549
A549/DDP
redox
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00043/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00043/full

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