Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis

Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis

Cellular metabolism and energy sensing pathways are closely linked to inflammation, but there is little understanding of how these pathways affect mast cell function. Mast cells are major effectors of allergy and asthma, and can be activated by the alarmin IL-33, which is linked to allergic disease....

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Bibliographic Details
Main Authors: Heather L. Caslin, Marcela T. Taruselli, Tamara Haque, Neha Pondicherry, Elizabeth A. Baldwin, Brian O. Barnstein, John J. Ryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
IL-33
mast cells
glycolysis
ATP
metabolism
metformin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03026/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03026/full

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