Cognitive Reserve Moderates Effects of White Matter Hyperintensity on Depressive Symptoms and Cognitive Function in Late-Life Depression

IntroductionWhite matter hyperintensity (WMH) has been regarded as one of the major contributor of the vascular hypothesis of late-life depression (LLD) and cognitive decline in the elderly. On the other hand, cognitive reserve (CR) has long been hypothesized to provide resilience and adaptability a...

Full description

Bibliographic Details
Main Authors: Chemin Lin, Chih-Mao Huang, Yang-Teng Fan, Ho-Ling Liu, Yao-Liang Chen, Howard J. Aizenstein, Tatia Mei-Chun Lee, Shwu-Hua Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.00249/full