Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs

Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs

Intestinal cholesterol absorption involves the chylomicron and HDL pathways and is dependent on microsomal triglyceride transfer protein (MTP) and ABCA1, respectively. Chylomicrons transport free and esterified cholesterol, whereas HDLs transport free cholesterol. ACAT2 esterifies cholesterol for se...

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Bibliographic Details
Main Authors: Jahangir Iqbal, Mohamed Boutjdir, Lawrence L. Rudel, M. Mahmood Hussain
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Journal of Lipid Research
Subjects:
microsomal triglyceride transfer protein
acyl-CoA:cholesterol acyltransferase 2
high density lipoproteins
chylomicrons
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520349798

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http://www.sciencedirect.com/science/article/pii/S0022227520349798

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