Design, Synthesis and Structure-Activity Relationships of Novel Chalcone-1,2,3-triazole-azole Derivates as Antiproliferative Agents

Design, Synthesis and Structure-Activity Relationships of Novel Chalcone-1,2,3-triazole-azole Derivates as Antiproliferative Agents

A series of novel chalcone-1,2,3-triazole-azole hybrids were designed, synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (SK-N-SH, EC-109 and MGC-803). Most of the synthesized compounds exhibited moderate to good activity against all the cancer c...

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Bibliographic Details
Main Authors: Sai-Yang Zhang, Dong-Jun Fu, Xiao-Xin Yue, Ying-Chao Liu, Jian Song, Hui-Hui Sun, Hong-Min Liu, Yan-Bing Zhang
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
chalcone-1,2,3-triazole-azole
synthesis
antiproliferative
morphological changes
Online Access:http://www.mdpi.com/1420-3049/21/5/653

Internet

http://www.mdpi.com/1420-3049/21/5/653

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