Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells

Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells

We previously reported the anticancer activity of 4-(4-fluorobenzylcarbamoylmethyl)-3-(4-cyclohexylphenyl)-2-[3-(N,N-dimethylureido)-N′-methylpropylamino]-3,4-dihydroquinazoline (OZ-001), a T-type calcium channel (TTCC) blocker, against non-small cell lung cancer (NSCLC) in vitro and in vivo. Here,...

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Bibliographic Details
Main Authors: Jeong-Hun Lee, Kyung-Sook Chung, Hwi-Ho Lee, Dohyeong Ko, Minji Kang, Ho Yoo, JooHoon Ahn, Jae Yeol Lee, Kyung-Tae Lee
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
OZ-001
Non-small cell lung cancer
Apoptosis
P70S6K
Combined therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221007435

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http://www.sciencedirect.com/science/article/pii/S0753332221007435

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