ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment

ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment

Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repai...

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Bibliographic Details
Main Authors: Chi-Fen Chen, Rolando Ruiz-Vega, Priya Vasudeva, Francisco Espitia, Tatiana B. Krasieva, Sebastien de Feraudy, Bruce J. Tromberg, Sharon Huang, Chad P. Garner, Jie Wu, Dave S. Hoon, Anand K. Ganesan
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Cell Reports
Subjects:
melanoma
ATR
macrophage
tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717302383

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http://www.sciencedirect.com/science/article/pii/S2211124717302383

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