Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo

Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo

Summary Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare disorder characterized by segmental accelerated aging and early death from coronary artery disease or stroke. Nearly 90% of HGPS sufferers carry a G608G mutation within exon 11 of LMNA, producing a truncated form of prelamin...

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Bibliographic Details
Main Authors: Vera Wenzel, Daniela Roedl, Diana Gabriel, Leslie B. Gordon, Meenhard Herlyn, Reinhard Schneider, Johannes Ring, Karima Djabali
Format: Article
Language:English
Published: The Company of Biologists 2012-04-01
Series:Biology Open
Subjects:
Lamin A
Progerin
HGPS
Progeria
Adult stem cells
Online Access:http://bio.biologists.org/content/1/6/516

Internet

http://bio.biologists.org/content/1/6/516

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