Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines

Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines

Background: The pathophysiology underlying altered blood-cerebrospinal fluid barrier (BCSFB) function in Alzheimer's disease (AD) is unknown but may relate to endothelial cell activation and cytokine mediated inflammation.Methods: Cerebrospinal fluid (CSF) and peripheral blood were concurrently...

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Bibliographic Details
Main Authors: Brian R. Ott, Richard N. Jones, Lori A. Daiello, Suzanne M. de la Monte, Edward G. Stopa, Conrad E. Johanson, Charles Denby, Paula Grammas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
blood brain barrier
choroid plexus
inflammation
Alzheimer
mild cognitive impairment (MCI)
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00245/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00245/full

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