Targeted genome engineering in human induced pluripotent stem cells by penetrating TALENs

Targeted genome engineering in human induced pluripotent stem cells by penetrating TALENs

Background: Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) have been successfully used to knock out endogenous genes in stem cell research. However, the deficiencies of current gene-based delivery systems may hamper the clinical application of these nucleas...

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Bibliographic Details
Main Authors: Renli Ru, Yongchao Yao, Songlin Yu, Benpeng Yin, Wanwan Xu, Siting Zhao, Li Qin, Xiaoping Chen
Format: Article
Language:English
Published: SpringerOpen 2013-01-01
Series:Cell Regeneration
Subjects:
CCR5
HIV-1
Cell-penetrating peptide
TALEN
TAT
Protein delivery
Induced pluripotent stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S204597691730041X

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http://www.sciencedirect.com/science/article/pii/S204597691730041X

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