Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Abstract Background Gut dysbiosis due to the adverse effects of antibiotics affects outcomes of lung infection. Previous murine models relied on significant depletion of both gut and lung microbiota, rendering the analysis of immune gut-lung cross-talk difficult. Here, we study the effects of antibi...

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Bibliographic Details
Main Authors: Rodrigue Dessein, Marvin Bauduin, Teddy Grandjean, Rémi Le Guern, Martin Figeac, Delphine Beury, Karine Faure, Christelle Faveeuw, Benoit Guery, Philippe Gosset, Eric Kipnis
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Critical Care
Subjects:
Antibiotics
Dysbiosis
Pseudomonas aeruginosa
Murine model
Flt3-ligand
Fecal microbial transplant
Online Access:http://link.springer.com/article/10.1186/s13054-020-03320-8

Internet

http://link.springer.com/article/10.1186/s13054-020-03320-8

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