Genome-wide CNV investigation suggests a role for cadherin, Wnt, and p53 pathways in primary open-angle glaucoma

Genome-wide CNV investigation suggests a role for cadherin, Wnt, and p53 pathways in primary open-angle glaucoma

Abstract Background To investigate whether copy number variations (CNVs) are implicated in molecular mechanisms underlying primary open-angle glaucoma (POAG), we used genotype data of POAG individuals and healthy controls from two case-control studies, AGS (n = 278) and GLGS-UGLI (n = 1292). PennCNV...

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Bibliographic Details
Main Authors: Valeria Lo Faro, Jacoline B. ten Brink, Harold Snieder, Nomdo M. Jansonius, Arthur A. Bergen
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Genomics
Subjects:
Primary open-angle glaucoma
CNV
WNT signalling
p53
Cell adhesion
Online Access:https://doi.org/10.1186/s12864-021-07846-1

Internet

https://doi.org/10.1186/s12864-021-07846-1

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