Anti-C1q Antibodies as Occurring in Systemic Lupus Erythematosus Could Be Induced by an Epstein-Barr Virus-Derived Antigenic Site

Anti-C1q Antibodies as Occurring in Systemic Lupus Erythematosus Could Be Induced by an Epstein-Barr Virus-Derived Antigenic Site

Previous infection with Epstein-Barr virus (EBV) is believed to trigger autoimmunity and to drive autoantibody generation as occurring in patients with systemic lupus erythematosus (SLE). Complement C1q and autoantibodies targeting it (anti-C1q) are also considered to be involved in the pathogenesis...

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Bibliographic Details
Main Authors: Kinga Csorba, Lucia A. Schirmbeck, Eylul Tuncer, Camillo Ribi, Pascale Roux-Lombard, Carlo Chizzolini, Uyen Huynh-Do, Dominique Vanhecke, Marten Trendelenburg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
anti-C1q antibody
A08 epitope
Epstein-Barr virus
EBNA-1
C1q deficient mice
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02619/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02619/full

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