PSORS1C1 Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical Study in Han Chinese

PSORS1C1 Hypomethylation Is Associated with Allopurinol-Induced Severe Cutaneous Adverse Reactions during Disease Onset Period: A Multicenter Retrospective Case-Control Clinical Study in Han Chinese

Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions. Evidence is growing that epigenetic variation...

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Bibliographic Details
Main Authors: Bao Sun, Lin Cheng, Yan Xiong, Lei Hu, Zhiying Luo, Maosong Zhou, Ji Li, Hongfu Xie, Fazhong He, Xiaoqing Yuan, Xiaoping Chen, Hong-Hao Zhou, Zhaoqian Liu, Xiang Chen, Wei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
allopurinol-SCARs
DNA methylation
HM450
methylated genes
PSORS1C1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00923/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00923/full

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