Investigation of new candidate genes in retinoblastoma using the TruSight One “clinical exome” gene panel

Investigation of new candidate genes in retinoblastoma using the TruSight One “clinical exome” gene panel

Abstract Background Retinoblastoma (Rb) is the most prevalent intraocular pediatric malignancy of the retina. Significant genetic factors are known to have a role in the development of Rb. Methods Here, we report the mutation status of 4813 clinically significant genes in six patients with noncarrie...

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Bibliographic Details
Main Authors: Demet Akdeniz, Seref Bugra Tuncer, Rejin Kebudi, Betul Celik, Gozde Kuru, Seda Kilic, Ozge Sukruoglu Erdogan, Mukaddes Avsar, Sema Buyukkapu Bay, Samuray Tuncer, Hulya Yazici
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
mutation
next‐generation sequencing
RB1 gene
retinoblastoma
retinoic acid pathway
Online Access:https://doi.org/10.1002/mgg3.785

Internet

https://doi.org/10.1002/mgg3.785

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