Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell lineages: a classical lineage of activated and...

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Bibliographic Details
Main Authors: Henry J. Sutton, Racheal Aye, Azza H. Idris, Rachel Vistein, Eunice Nduati, Oscar Kai, Jedida Mwacharo, Xi Li, Xin Gao, T. Daniel Andrews, Marios Koutsakos, Thi H.O. Nguyen, Maxim Nekrasov, Peter Milburn, Auda Eltahla, Andrea A. Berry, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Adam K. Wheatley, Stephen J. Kent, Stephen L. Hoffman, Kirsten E. Lyke, Philip Bejon, Fabio Luciani, Katherine Kedzierska, Robert A. Seder, Francis M. Ndungu, Ian A. Cockburn
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
B cell memory
atypical B cells
alternative B cell lineage
malaria
sporozoite
vaccination
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720316739

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http://www.sciencedirect.com/science/article/pii/S2211124720316739

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