Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
Summary: The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell lineages: a classical lineage of activated and...
Main Authors: | Henry J. Sutton, Racheal Aye, Azza H. Idris, Rachel Vistein, Eunice Nduati, Oscar Kai, Jedida Mwacharo, Xi Li, Xin Gao, T. Daniel Andrews, Marios Koutsakos, Thi H.O. Nguyen, Maxim Nekrasov, Peter Milburn, Auda Eltahla, Andrea A. Berry, Natasha KC, Sumana Chakravarty, B. Kim Lee Sim, Adam K. Wheatley, Stephen J. Kent, Stephen L. Hoffman, Kirsten E. Lyke, Philip Bejon, Fabio Luciani, Katherine Kedzierska, Robert A. Seder, Francis M. Ndungu, Ian A. Cockburn |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-02-01
|
Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124720316739 |
Similar Items
-
Antibody and B cell responses to Plasmodium sporozoites
by: Johanna N Dups, et al.
Published: (2014-11-01) -
Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites
by: Tanmaya Atre, et al.
Published: (2019-05-01) -
Human B1 cell Frequency: Isolation and Analysis of Human B1 Cells
by: Daniel eGriffin, et al.
Published: (2012-05-01) -
B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients
by: Víctor A. Sosa-Hernández, et al.
Published: (2020-12-01) -
B Cell Modulation Strategies in Autoimmune Diseases: New Concepts
by: Philippe Musette, et al.
Published: (2018-04-01)