A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer’s Disease and Frontotemporal Dementia Disease Modeling

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer’s Disease and Frontotemporal Dementia Disease Modeling

The study of neurodegenerative diseases using pluripotent stem cells requires new methods to assess neurodevelopment and neurodegeneration of specific neuronal subtypes. The cholinergic system, characterized by its use of the neurotransmitter acetylcholine, is one of the first to degenerate in Alzhe...

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Bibliographic Details
Main Authors: Sonia Sanz Muñoz, Martin Engel, Rachelle Balez, Dzung Do-Ha, Mauricio Castro Cabral-da-Silva, Damian Hernández, Tracey Berg, Jennifer A. Fifita, Natalie Grima, Shu Yang, Ian P. Blair, Garth Nicholson, Anthony L. Cook, Alex W. Hewitt, Alice Pébay, Lezanne Ooi
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
induced pluripotent stem cells
disease modelling
neuronal differentiation
cholinergic neurons
Alzheimer’s disease
frontotemporal dementia
Online Access:https://www.mdpi.com/2073-4409/9/9/2018

Internet

https://www.mdpi.com/2073-4409/9/9/2018

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