Discovery of Novel eEF2K Inhibitors Using HTS Fingerprint Generated from Predicted Profiling of Compound-Protein Interactions

Discovery of Novel eEF2K Inhibitors Using HTS Fingerprint Generated from Predicted Profiling of Compound-Protein Interactions

<b>Background:</b> Eukaryotic elongation factor 2 kinase (eEF2K) regulates the elongation stage of protein synthesis by phosphorylating eEF2, a process related to various diseases including cancer and cardiovascular and neurodegenerative diseases. In this study, we describe the identific...

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Bibliographic Details
Main Authors: Atsushi Yoshimori, Enzo Kawasaki, Ryuta Murakami, Chisato Kanai
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Medicines
Subjects:
eEF2K—Eukaryotic elongation factor-2 kinase
CGBFP—chemical genomics-based fingerprint
CGBVS—Chemical Genomics-Based Virtual Screening
CGBSP—Chemical Genomics-Based Similarity Profiling
Online Access:https://www.mdpi.com/2305-6320/8/5/23

Internet

https://www.mdpi.com/2305-6320/8/5/23

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