Computational Identification and Modeling of Crosstalk between Phosphorylation, O-β-glycosylation and Methylation of FoxO3 and Implications for Cancer Therapeutics

Computational Identification and Modeling of Crosstalk between Phosphorylation, O-β-glycosylation and Methylation of FoxO3 and Implications for Cancer Therapeutics

FoxO3 is a member of the forkhead class of transcription factors and plays a major role in the regulation of diverse cellular processes, including cell cycle arrest, DNA repair, and protection from stress stimuli by detoxification of reactive oxygen species. In addition, FoxO3 is a tumor suppressor...

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Bibliographic Details
Main Authors: Yigang Tong, Jun Lu, Muhammad Idrees, Dandan Feng, Azeem Mehmood Butt
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:International Journal of Molecular Sciences
Subjects:
FoxO3
FoxO
in silico
posttranslational modifications
phosphorylation
O-β-glycosylation
methylation
cancer
Yin Yang sites
Online Access:http://www.mdpi.com/1422-0067/13/3/2918/

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http://www.mdpi.com/1422-0067/13/3/2918/

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