Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

Cohesin’s association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during G1 in S. cerevisiae cells. It does so by blocking a Wapl-independent release reaction that requires op...

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Bibliographic Details
Main Authors: Madhusudhan Srinivasan, Naomi J Petela, Johanna C Scheinost, James Collier, Menelaos Voulgaris, Maurici B Roig, Frederic Beckouët, Bin Hu, Kim A Nasmyth
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
Cohesin
CDK1
sister chromatid cohesion
loop extrusion
Wapl
SMC
Online Access:https://elifesciences.org/articles/44736

Internet

https://elifesciences.org/articles/44736

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