Scc2 counteracts a Wapl-independent mechanism that releases cohesin from chromosomes during G1

Cohesin’s association with chromosomes is determined by loading dependent on the Scc2/4 complex and release due to Wapl. We show here that Scc2 also actively maintains cohesin on chromosomes during G1 in S. cerevisiae cells. It does so by blocking a Wapl-independent release reaction that requires op...

Full description

Bibliographic Details
Main Authors: Madhusudhan Srinivasan, Naomi J Petela, Johanna C Scheinost, James Collier, Menelaos Voulgaris, Maurici B Roig, Frederic Beckouët, Bin Hu, Kim A Nasmyth
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
SMC
Online Access:https://elifesciences.org/articles/44736