Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic?

Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic?

Objectives: In this study, we examined the possibility of using targeted antibodies and the potential of small molecular therapeutics (acetylcholine, nicotine and tacrine) to block the pro-inflammatory and adhesion-related properties of monomeric C-reactive protein (mCRP).Methods: We used three esta...

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Bibliographic Details
Main Authors: Mark Slevin, Rocco S. Iemma, Yasmin Zeinolabediny, Donghui Liu, Glenn R. Ferris, Vittorio Caprio, Nicola Phillips, Mario Di Napoli, Baoqiang Guo, Xianwei Zeng, Raid AlBaradie, Naif K. Binsaleh, Garry McDowell, Wen-Hui Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
CRP
inflammation
cell adhesion
acetylcholine
nicotine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02124/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02124/full

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