Poly(ethylene glycol)-<i>b</i>-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Poly(ethylene glycol)-<i>b</i>-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-<i>b</i>-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-...

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Bibliographic Details
Main Authors: Silvio Curia, Feifei Ng, Marie-Emérentienne Cagnon, Victor Nicoulin, Adolfo Lopez-Noriega
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
long acting injectables
aliphatic polycarbonates
acylation
polyesters
poly(lactic acid)
amphiphilic copolymers
Online Access:https://www.mdpi.com/1420-3049/26/5/1438

Internet

https://www.mdpi.com/1420-3049/26/5/1438

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