Multi-objective optimization of tumor response to drug release from vasculature-bound nanoparticles

Abstract The pharmacokinetics of nanoparticle-borne drugs targeting tumors depends critically on nanoparticle design. Empirical approaches to evaluate such designs in order to maximize treatment efficacy are time- and cost-intensive. We have recently proposed the use of computational modeling of nan...

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Bibliographic Details
Main Authors: Ibrahim M. Chamseddine, Hermann B. Frieboes, Michael Kokkolaras
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-65162-2