Tetracycline Analogs Inhibit Osteoclast Differentiation by Suppressing MMP-9-Mediated Histone H3 Cleavage

Tetracycline Analogs Inhibit Osteoclast Differentiation by Suppressing MMP-9-Mediated Histone H3 Cleavage

Osteoporosis is a common disorder of bone remodeling, caused by the imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Recently, we reported that matrix metalloproteinase-9 (MMP-9)-dependent histone H3 proteolysis is a key event for proficient osteoclast formation. A...

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Bibliographic Details
Main Authors: Yeojin Kim, Jinman Kim, Hyerim Lee, Woo-Ri Shin, Sheunghun Lee, Jisu Lee, Jae-Il Park, Byung Hak Jhun, Yang-Hoon Kim, Sun-Ju Yi, Kyunghwan Kim
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
tigecycline
minocycline
MMP-9
osteoclast
histone cleavage
osteoporosis
Online Access:https://www.mdpi.com/1422-0067/20/16/4038

Internet

https://www.mdpi.com/1422-0067/20/16/4038

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