Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas

Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas

Abstract Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M–mutant is a new entity introduced to HGG in the latest WHO classification. In this study we evaluated the presence of H3K27M mutation in 105 tumo...

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Bibliographic Details
Main Authors: Amal Mosaab, Moatasem El-Ayadi, Eman N. Khorshed, Nada Amer, Amal Refaat, Mohamed El-Beltagy, Zeinab Hassan, Sameh H. Soror, Mohamed Saad Zaghloul, Shahenda El-Naggar
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-65272-x

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https://doi.org/10.1038/s41598-020-65272-x

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