Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

Topoisomerase II (TOP2) relieves topological stress in DNA by introducing double-strand breaks (DSBs) via a transient, covalently linked TOP2 DNA-protein intermediate, termed TOP2 cleavage complex (TOP2cc). TOP2ccs are normally rapidly reversible, but can be stabilized by TOP2 poisons, such as the c...

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Bibliographic Details
Main Authors: Nicholas Sciascia, Wei Wu, Dali Zong, Yilun Sun, Nancy Wong, Sam John, Darawalee Wangsa, Thomas Ried, Samuel F Bunting, Yves Pommier, André Nussenzweig
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
topoisomerases
cancer
DNA repair
genome instability
DNA damage
Online Access:https://elifesciences.org/articles/53447

Internet

https://elifesciences.org/articles/53447

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