Microdissection of the Bulk Transcriptome at Single-Cell Resolution Reveals Clinical Significance and Myeloid Cells Heterogeneity in Lung Adenocarcinoma

Microdissection of the Bulk Transcriptome at Single-Cell Resolution Reveals Clinical Significance and Myeloid Cells Heterogeneity in Lung Adenocarcinoma

BackgroundTumor infiltrating myeloid (TIM) cells constitute a vital element of the tumor microenvironment. The cell-type heterogeneity of TIM has yet to be fully investigated.MethodsWe used a time saving approach to generate a single-cell reference matrix, allowing quantification of cell-type propor...

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Bibliographic Details
Main Authors: Hao Wu, Jiale Qin, Qiang Zhao, Lu Lu, Chen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
tumor infiltrating myeloid cells
lung adenocarcinoma
single-cell transcriptome analysis
bulk RNA-seq analysis
deconvolution
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.723908/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.723908/full

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