Activation of the C-Type Lectin MGL by Terminal GalNAc Ligands Reduces the Glycolytic Activity of Human Dendritic Cells

Activation of the C-Type Lectin MGL by Terminal GalNAc Ligands Reduces the Glycolytic Activity of Human Dendritic Cells

Many tumors display alterations in the biosynthetic pathways of glycosylation, resulting in increased expression of specific tumor-associated glycan structures. Expression of these altered glycan structures is associated with metastasis and poor prognosis. Antigen presenting cells can recognize tumo...

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Bibliographic Details
Main Authors: Anouk Zaal, R. J. Eveline Li, Joyce Lübbers, Sven C. M. Bruijns, Hakan Kalay, Yvette van Kooyk, Sandra J. van Vliet
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
macrophage galactose-type lectin
antigen presenting cells
tumor-associated glycans
metabolism
glycolysis
oxidative phosphorylation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00305/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00305/full

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