A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics

A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics

Cell-based assays are an attractive option to measure gene expression response to exposure, but the cost of whole-transcriptome RNA sequencing has been a barrier to the use of gene expression profiling for in vitro toxicity screening. In addition, standard RNA sequencing adds variability due to vari...

Full description

Bibliographic Details
Main Authors: John S. House, Fabian A. Grimm, Dereje D. Jima, Yi-Hui Zhou, Ivan Rusyn, Fred A. Wright
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Genetics
Subjects:
expression-based dose–response modeling
dose–response modeling
bioinformatics-pipeline
toxicogenomics
bioinformatics & computational biology
iPSCs
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2017.00168/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2017.00168/full

Similar Items