Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease

Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease

Animal models have significantly advanced our understanding of Parkinson’s disease (PD). Alpha-synuclein (α-syn) has taken center stage due to its genetic connection to familial PD and localization to Lewy bodies, one pathological hallmark of PD. Animal models developed on the premise of elevated al...

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Bibliographic Details
Main Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, D. Luke Fischer, Anna C. Stoll, Caryl E. Sortwell
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
alpha-synuclein
preformed fibrils
synucleinopathy
animal models
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00621/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00621/full

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