UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins

UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins

Activation of the integrated stress response (ISR), alterations in nucleo-cytoplasmic (N/C) transport and changes in alternative splicing regulation are all common traits of the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). However, whether these processes act independently from each other, o...

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Bibliographic Details
Main Authors: Simona Rossi, Valentina Rompietti, Ylenia Antonucci, Daniela Giovannini, Chiara Scopa, Silvia Scaricamazza, Raffaella Scardigli, Gianluca Cestra, Annalucia Serafino, Maria Teresa Carrì, Nadia D'Ambrosi, Mauro Cozzolino
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Neurobiology of Disease
Subjects:
ALS
Nucleo-cytoplasmic transport
Integrated stress response
Stress granules
Cajal bodies
Gems
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030067X

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http://www.sciencedirect.com/science/article/pii/S096999612030067X

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