C-Fos regulation by the MAPK and PKC pathways in intervertebral disc cells.

BACKGROUND: The gene encoding c-fos is an important factor in the pathogenesis of joint disease in patients with osteoarthritis. However, it is unknown whether the signal mechanism of c-fos acts in intervertebral disc (IVD) cells. We investigated whether c-fos is activated in relation to mitogen-act...

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Bibliographic Details
Main Authors: Katsuya Yokoyama, Akihiko Hiyama, Fumiyuki Arai, Tadashi Nukaga, Daisuke Sakai, Joji Mochida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3759433?pdf=render