Omega-3 polyunsaturated fatty acids mitigate blood–brain barrier disruption after hypoxic–ischemic brain injury

Omega-3 polyunsaturated fatty acids mitigate blood–brain barrier disruption after hypoxic–ischemic brain injury

Omega-3 polyunsaturated fatty acids (n‐3 PUFAs) have been shown to protect the neonatal brain against hypoxic/ischemic (H/I) injury. However, the mechanism of n‐3 PUFA-afforded neuroprotection is not well understood. One major determinant of H/I vulnerability is the permeability of the blood–brain b...

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Bibliographic Details
Main Authors: Wenting Zhang, Hui Zhang, Hongfeng Mu, Wen Zhu, Xiaoyan Jiang, Xiaoming Hu, Yejie Shi, Rehana K. Leak, Qiang Dong, Jun Chen, Yanqin Gao
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Neurobiology of Disease
Subjects:
Hypoxia/ischemia
Blood brain barrier
MMP-9
MMP-2
Tight junction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300389

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http://www.sciencedirect.com/science/article/pii/S0969996116300389

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