Evidence that GRIN2A mutations in melanoma correlate with decreased survival

Evidence that GRIN2A mutations in melanoma correlate with decreased survival

Previous whole-exome sequencing has demonstrated that melanoma tumours harbour mutations in the GRIN2A gene. GRIN2A encodes the regulatory GluN2A subunit of the glutamate-gated N-methyl-D-aspartate receptor (NMDAR), involvement of which in melanoma remains undefined. Here, we sequenced coding exons...

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Bibliographic Details
Main Authors: Stacey Ann N D'mello, Jack U Flanagan, Taryn N Green, Euphemia Y Leung, Marjan E Askarian-Amiri, Wayne R Joseph, Michael R McCrystal, Richard J Isaacs, James H F Shaw, Christopher E Furneaux, Matthew J During, Graeme J FInlay, Bruce C Baguley, Maggie Lucy Kalev-Zylinska
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Oncology
Subjects:
Melanoma
Mutation
Glutamate
biomarker
prognosis
NMDA receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00333/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00333/full

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