The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.

The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.

Precursor-B cell receptor (pre-BCR) signaling represents a crucial checkpoint at the pre-B cell stage. Aberrant pre-BCR signaling is considered as a key factor for B-cell precursor acute lymphoblastic leukemia (BCP-ALL) development. BCP-ALL are believed to be arrested at the pre-BCR checkpoint indep...

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Bibliographic Details
Main Authors: Dongfeng Chen, Junxiong Zheng, Natalija Gerasimcik, Kristina Lagerstedt, Helene Sjögren, Jonas Abrahamsson, Linda Fogelstrand, Inga-Lill Mårtensson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5017602?pdf=render

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http://europepmc.org/articles/PMC5017602?pdf=render

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