Meningitic Escherichia coli α-hemolysin aggravates blood–brain barrier disruption via targeting TGFβ1-triggered hedgehog signaling

Meningitic Escherichia coli α-hemolysin aggravates blood–brain barrier disruption via targeting TGFβ1-triggered hedgehog signaling

Abstract Bacterial meningitis is a life-threatening infectious disease with severe neurological sequelae and a high mortality rate, in which Escherichia coli is one of the primary Gram-negative etiological bacteria. Meningitic E. coli infection is often accompanied by an elevated blood–brain barrier...

Full description

Bibliographic Details
Main Authors: Jiyang Fu, Liang Li, Dong Huo, Ruicheng Yang, Bo Yang, Bojie Xu, Xiaopei Yang, Menghong Dai, Chen Tan, Huanchun Chen, Xiangru Wang
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Brain
Subjects:
Escherichia coli
α-Hemolysin
Blood–brain barrier
Intercellular communication
TGFβ1
Hedgehog signaling
Online Access:https://doi.org/10.1186/s13041-021-00826-2

Internet

https://doi.org/10.1186/s13041-021-00826-2

Similar Items