Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage

Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage

Regulatory T cells (Tregs) restrict overexuberant lymphocyte activation. While close proximity between Tregs and their suppression targets is important for optimal inhibition, and literature indicates that draining lymph nodes (LNs) may serve as a prime location for the suppression, signaling detail...

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Bibliographic Details
Main Authors: Shuang Geng, Yiwei Zhong, Xiaoyu Zhou, Gan Zhao, Xiaoping Xie, Yechun Pei, Hu Liu, Huiyuan Zhang, Yan Shi, Bin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
inducible regulatory T cell
antigen specific suppression
hilar lymph node
airway inflammation
egress
S1p1
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00663/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00663/full

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