Oxidized Low-Density Lipoprotein Induces WNT5A Signaling Activation in THP-1 Derived Macrophages and a Human Aortic Vascular Smooth Muscle Cell Line

Oxidized Low-Density Lipoprotein Induces WNT5A Signaling Activation in THP-1 Derived Macrophages and a Human Aortic Vascular Smooth Muscle Cell Line

The pathogenesis of atherosclerosis is complex, evolves, and involves many cell types. Macrophages and vascular smooth muscle cells (VSMCs) are critically involved in atherosclerosis development and progression. Several studies have shown that WNT5A protein is abundantly expressed in human atheroscl...

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Bibliographic Details
Main Authors: Ian Ackers, Candice Szymanski, Mitchell J. Silver, Ramiro Malgor
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
macrophages
vascular smooth muscle cells
foam cells
Wnt signaling
vascular biology
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.567837/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2020.567837/full

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