Mechanisms Underlying H2O2-Evoked Carbonyl Modification of Cytoskeletal Protein and Axon Injury in PC-12 Cells

Mechanisms Underlying H2O2-Evoked Carbonyl Modification of Cytoskeletal Protein and Axon Injury in PC-12 Cells

Background/Aims: To investigate the mechanism that enables oxidative stress and cytoskeleton protein carbonylation to contribute to axonal dysfunction in traumatic brain injury (TBI). Methods: We created an in vitro model of neuronal oxidative damage by exposing a neuron-like cell line (PC-12) to di...

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Bibliographic Details
Main Authors: Xiejun Zhang, Zongyang Li, Qiusheng Zhang, Lei Chen, Xianjian Huang, Yuan Zhang, Xiaojia Liu, Wenlan Liu, Weiping Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Traumatic brain injury
Oxidative stress
Cytoskeletal protein
Carbonylation
Axonal injury
Proteasome β5 subunit
Online Access:https://www.karger.com/Article/FullText/491975

Internet

https://www.karger.com/Article/FullText/491975

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