FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E.

FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E.

BACKGROUND: FUS-DDIT3 is a chimeric protein generated by the most common chromosomal translocation t(12;16)(q13;p11) linked to liposarcomas, which are characterized by the accumulation of early adipocytic precursors. Current studies indicate that FUS-DDIT3- liposarcoma develops from uncommitted prog...

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Bibliographic Details
Main Authors: Pedro A Pérez-Mancera, Camino Bermejo-Rodríguez, Manuel Sánchez-Martín, Fernando Abollo-Jiménez, Belén Pintado, Isidro Sánchez-García
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2434200?pdf=render

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http://europepmc.org/articles/PMC2434200?pdf=render

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