Dihydropyrimidine dehydrogenase mutation in neoadjuvant chemotherapy in head and neck cancers: Myth or reality?

Dihydropyrimidine dehydrogenase mutation in neoadjuvant chemotherapy in head and neck cancers: Myth or reality?

Purpose: The docetaxel, 5-fluorouracil (5-FU), and cisplatin (TPF) regimen in India is associated with high percentages of Grade 3-4 toxicity. This analysis was planned to evaluate the incidence of dihydropyrimidine dehydrogenase (DPD) mutation in patients with severe gastrointestinal toxicity, to a...

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Bibliographic Details
Main Authors: Vijay M Patil, Vanita Noronha, Amit Joshi, Saurabh Zanwar, Anant Ramaswamy, Supreeta Arya, Abhishek Mahajan, Atanu Bhattacharjee, Kumar Prabhash
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2016-01-01
Series:South Asian Journal of Cancer
Subjects:
5-fluorouracil
dihydropyrimidine dehydrogenase mutation
head and neck cancers
neoadjuvant chemotherapy
toxicity
Online Access:http://journal.sajc.org/article.asp?issn=2278-330X;year=2016;volume=5;issue=4;spage=182;epage=185;aulast=Patil

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http://journal.sajc.org/article.asp?issn=2278-330X;year=2016;volume=5;issue=4;spage=182;epage=185;aulast=Patil

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