Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder

Targeting redox-altered plasticity to reactivate synaptic function: A novel therapeutic strategy for cognitive disorder

Redox-altered plasticity refers to redox-dependent reversible changes in synaptic plasticity via altering functions of key proteins, such as N-methyl-d-aspartate receptor (NMDAR). Age-related cognitive disorders includes Alzheimer's disease (AD), vascular dementia (VD), and age-associated memor...

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Bibliographic Details
Main Authors: Pei Wang, Fang Wang, Lan Ni, Pengfei Wu, Jianguo Chen
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Reactive oxygen species
N-Methyl-d-aspartate receptor
Oxidative stress
Synaptic plasticity
Long-term potentiation
Cognitive disorder
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520308029

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http://www.sciencedirect.com/science/article/pii/S2211383520308029

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