Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists

Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists

BackgroundBitter-taste receptors (TAS2Rs) are involved in airway relaxation but are also expressed in human blood leukocytes. We studied TAS2R expression and the effects of TAS2R agonists on the lipopolysaccharide (LPS)-induced cytokine release in human lung macrophages (LMs).MethodsLung macrophages...

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Bibliographic Details
Main Authors: Stanislas Grassin-Delyle, Hélène Salvator, Nikola Mantov, Charlotte Abrial, Marion Brollo, Christophe Faisy, Emmanuel Naline, Louis-Jean Couderc, Philippe Devillier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physiology
Subjects:
bitter taste receptor
human lung macrophage
parenchyma explant
cytokine
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01267/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01267/full

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