Cartilage-specific overexpression of ERRγ results in Chondrodysplasia and reduced chondrocyte proliferation.

While the role of estrogen receptor-related receptor alpha (ERRα) in chondrogenesis has been investigated, the involvement of ERR gamma (ERRγ) has not been determined. To assess the effect of increased ERRγ activity on cartilage development in vivo, we generated two transgenic (Tg) lines overexpress...

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Bibliographic Details
Main Authors: Marco Cardelli, Ralph A Zirngibl, Jonathan F Boetto, Kristen P McKenzie, Tammy-Claire Troy, Kursad Turksen, Jane E Aubin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3857204?pdf=render